Poly Vs Natural Gut

If you still want to experiment with the natural gut in a hybrid, the general rule is that using the gut in the mains will give the set up more gut characteristics than in the crosses. If you use the gut in a hybrid, you may find you only have to go up on the tension minimally. source

This would also assume you are playing with strings that are not frayed too bad. I had gut snap in my bag when it was around 40s outside. source

I decided to go back to using synthetic gut strings and now I wonder why I ever changed. I have tried just about everything out there except gut. source

One thing i've noticed about stringing gut over the years is it's very hard to tell much about playability just holding it in my hands, especially before a light pre-stretch. I have found the same with poly, I have some that feel brittle and play on the soft side and I have found some that feel nice and flexy in hand only to end up feeling too dead and harsh. With strings you never know until you hit some balls. source

Stepanek, Haas, Takao Suzuki, Davenport, Mauresmo, Henin come into my mind at the first moment who use full gut. With gut hybrid we have plenty like Federer or Roddick. source