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On Thu, 11 Jun 2009 12:50:37 -0700 (PDT), randall <...@aol.com
HI,
GRAY or WHITE hair and bleach?
Only his/her hairdresser knows for sure. <w
Let me think about this one. I tend to think YES, that folks with
autoimmune problems
do gray/go white a lot sooner.
IIRC it's in this group. The science that is.
-------------------
So go look for it.
I went looking for an abstract with PMID: 19389933
earlier today.
And i couldn't find it in a search of our group.
See for your self:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?hl=en &group=alt.support.skin-diseases.psoriasis&q=PMID%3A+19389933&qt_g=Search+this+g roup
In our group i'm still unsearchable.
Yikes my hair is turning white. LOL
But not in china:
http://groups.google.co.kr/group/alt.support.skin-diseases.psoriasis/browse_thr ead/thread/2379b42018ce0a77
After reading MY posts/threads from last night, i wanted to
look at th17 and anything that influences RORgammat.
And Am80 from Japan fits that bill and I KNEW i had posted it
recently.
So i had to manually go find it.
Here's the abstract I was looking for:
http://www.ncbi.nlm.nih.gov/pubmed/19389933
Synthetic retinoid AM80 inhibits Th17 cells and ameliorates
experimental autoimmune encephalomyelitis.
Klemann C, Raveney BJ, Klemann AK, Ozawa T, von Hörsten S, Shudo K,
Oki S, Yamamura T.
Director, Department of Immunology, or Shinji Oki, Ph.D., Section
Chief, Department of Immunology, National Institute of Neuroscience,
NCNP, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Recent evidence suggests that interleukin-17-producing CD4(+) T cells
(Th17 cells) are the dominant pathogenic cellular component in
autoimmune inflammatory diseases, including multiple sclerosis. It
has
recently been demonstrated that all-trans retinoic acid can suppress
Th17 differentiation and promote the generation of Foxp3(+)
regulatory
T cells via retinoic acid receptor signals. Here, we investigated the
effects of AM80, a synthetic retinoid with enhanced biological
properties to all-trans retinoic acid, on Th17 differentiation and
function and evaluated its therapeutic potential in experimental
autoimmune encephalomyelitis (EAE), an animal model of multiple
sclerosis. AM80 treatment was more effective than all-trans retinoic
acid in inhibiting Th17 differentiation in vitro. Oral administration
of AM80 was protective for the early development of EAE and the down-
modulation of Th17 differentiation and effector functions in vivo.
Moreover, AM80 inhibited interleukin-17 production by splenic memory
T
cells, in vitro-differentiated Th17 cells, and central nervous
system-
infiltrating effector T cells. Accordingly, AM80 was effective when
administered therapeutically after the onset of EAE. Continuous AM80
treatment, however, was ineffective at inhibiting late EAE symptoms
despite the maintained suppression of RORgammat and interleukin-17
expression levels by central nervous system-infiltrating T cells. We
reveal that continuous AM80 treatment also led to the suppression of
interleukin-10 production by a distinct T cell subset that expressed
both Foxp3 and RORgammat. These findings suggest that retinoid
signaling regulates both inflammatory Th17 cells and Th17-like
regulatory cells.
PMID: 19389933
See, it is easy to find me in china:
http://www.google.com/search?hl=en&q=PMID%3A+19389933+randall&aq=f&oq=&aqi=
So while i've posted 21 times in June so far, you or I can't google
them.
Unless i go via china, which it appears is becoming freer then the US
of A
these days, I can't find THEM. LOL
Why do i have to shut uP?
I have things to say.
If you don't like them, fine.
I don't like what i hear on the mainstream media and simply turn it
off.
No problem.
If you have a problem with me then let's chat.
So i can pull the log from your eye and you can search
for the sliver in mine. LOL
==================
So?
WILL the randall coP to being manic? Or a maniac?
http://en.wikipedia.org/wiki/Mania
No, but i'd love some low dose lithium to slow things down.
(LDL is swell... lol)
It would most likely cut these posts down by 50%?
Would you like that? LOL
But de novo effects may have the oPPosite effect and increase
my so called ramblings by 75%? :)
http://en.wikipedia.org/wiki/Lithium
But once we get all the flakes, manica's and gov workers
on lithium there won't be enough left over to power batteries. LOL
What will we do once we have nuclear power to top off
batteries, but not enough lithium?
That stuff is gonna get expensive.
http://www.ncbi.nlm.nih.gov/pubmed/19512974
Lithium, antipsychotics, and risk of psoriasis.
Brauchli YB, Jick SS, Curtin F, Meier CR.
Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and
Toxicology, University Hospital Basel, Basel, Switzerland.
BACKGROUND: Observations in controlled trials and case reports have
linked lithium exposure to induction or exacerbation of psoriasis. A
causal relationship between lithium exposure and incident psoriasis
has been questioned, and observational studies are lacking. METHODS:
We conducted a case-control analysis using the United Kingdom-based
General Practice Research Database to study the association between
the use of lithium or antipsychotics and the risk of developing an
incident diagnosis of psoriasis. We identified cases with an incident
diagnosis of psoriasis between 1994 and 2005, and controls were
matched to the cases on age, sex, general practice, calendar time, and
years of history in the database. We used conditional logistic
regression to estimate the risk of developing a first-time diagnosis
of psoriasis in relation to previous exposure to lithium and
antipsychotic drugs, stratified by exposure timing and duration. We
calculated odds ratios (ORs) with 95% confidence intervals (CIs)
adjusted for smoking, body mass index, and additional potential
confounders. RESULTS: We identified 36,702 incident cases of psoriasis
and the same number of matched controls. Compared with nonuse, current
use of 5 or more prescriptions for lithium and atypical antipsychotics
yielded adjusted ORs of 1.68 (95% CI, 1.18-2.39; P < 0.01) and 0.76
(95% CI, 0.55-1.06; P = 0.11), respectively. The OR for olanzapine was
0.50 (95% CI, 0.28-0.89, P = 0.02). CONCLUSIONS: Long-term use of
lithium was associated with a small increase in risk of incident
psoriasis. There was a suggestion of a possible reduced psoriasis risk
associated with the use of atypical antipsychotics, mainly olanzapine,
a finding that needs further evaluation.
PMID: 19512974
olanzapine (zyprexa -- bipolar etc)
http://en.wikipedia.org/wiki/Olanzapine
It would seem that lithium would work if it doesn't flare you.
http://en.wikipedia.org/wiki/Lithium#Medical_use
But low dose lithium orotate can cure more serious problems that
will help you to regain control over your life?
Are you on the fringe?
Check it out:
http://www.digitalnaturopath.com/treat/T28305.html
The Analyst - Internet Health Report: Treatment: Lithium (low dose)
LOW dose lithium for or to prevent alzheimer's
http://www.brighthub.com/health/alternative-medicine/articles/17393.aspx
[...]
Some alternative medicine practitioners have touted the benefits of
low dose lithium supplements for a healthy brain. Dr. Jonathan V.
Wright M.D. claims that lithium orotate or lithium aspartate can
increase gray matter in the brain without the harmful side effects
associated with high doses of lithium carbonate. Lithium carbonate is
a prescription medication that is used to treat bipolar disorder by
the psychiatric community. High doses of lithium carbonate need to be
taken to see results. Typical doses are in the range of 300 mg to 900
mg. Lithium orotate and lithium aspartate are natural supplements that
can be found in health food stores. Dr. Wright and other alternative
health care practitioners claim that both lithium orotate and
aspartate are harmless and free from side effects because only 5 to 20
milligrams are needed to produce results. They say that the natural
supplements are utilized by the cells better than their prescription
counterpart and high doses are not needed.
<sniP
-------------------
What's up with LDN (low dose naltrexone )
http://talkpsoriasis.org/search.php?searchid=4116057
If you find anything new let me know.
So i can go with more OT... (ON toPic) threads. LOL <w
----------------
Vitamin D inducts LL-37/LL37
http://www.ncbi.nlm.nih.gov/pubmed/19389235
pmid: 19389235
http://www.ncbi.nlm.nih.gov/pubmed/18703682
pmid: 18703682
http://www.ncbi.nlm.nih.gov/pubmed/17513768
pmid: 17513768
LL37 causes more psoriasis through pathways not completely understood:
http://www.ncbi.nlm.nih.gov/pubmed/18611439
Antimicrobial peptides and self-DNA in autoimmune skin inflammation.
Gilliet M, Lande R.
Department of Immunology, The University of Texas MD Anderson Cancer
Center, Houston, TX 77030, USA. mgil...@mdanderson.org
Toll-like receptor (TLR)-mediated detection of viral nucleic acids and
production of type I interferons (IFNs) by plasmacytoid dendritic
cells (pDCs) are key elements of antiviral defense. By contrast,
inappropriate recognition of self-nucleic acids with induction of IFN
responses in pDCs can lead to autoimmunity. In this review we describe
how pDC responses to self-DNA are normally avoided and focus on our
recent finding that in psoriasis, a common autoimmune disease of the
skin, these barriers can be breached by the cationic antimicrobial
peptide LL37. LL37 binds extracellular self-DNA fragments into
aggregated particles that enter pDCs and trigger robust IFN responses
by activating endosomal TLR9 as if they were viruses. We also describe
the mechanisms that normally control production and activity of LL37
in human skin and propose that the persistent overexpression of LL37
in psoriasis leads to uncontrolled IFN responses that drive autoimmune
skin inflammation.
PMID: 18611439
Want to turn your tLR;s in to virus look alikes?
YIKES... say heck NO.
http://en.wikipedia.org/wiki/Toll_like_receptor
Toll-like receptors (TLRs) are a class of proteins that play a key
role in the adaptive immune system. They are single membrane-spanning
non-catalytic receptors that recognize structurally conserved
molecules derived from microbes. Once these microbes have breached
physical barriers such as the skin or intestinal tract mucosa, they
are recognized by TLRs which activates immune cell responses.
<sniP
http://en.wikipedia.org/wiki/TLR_9
TLR 9 is a toll-like receptor.
It recognizes unmethylated CpG sites on DNA molecules. CpG sites are
relatively rare (~1%) on vertebrate genomes in comparison to bacterial
genomes or viral DNA. TLR9 is expressed by numerous cells of the
immune system such as dendritic cells, B lymphocytes and natural
killer (NK) cells. TLR9 is expressed intracellularly, within the
endosomal compartments and functions to alert the immune system of
viral and bacterial infections by binding to DNA rich in CpG motifs.
TLR9 signals leads to activation of the cells initiating pro-
inflammatory reactions that result in the production of cytokines such
as type-I inteferon and IL-12. There are new immunomodulatory
treatments undergoing testing which involve the administration of
artificial DNA oligonucleotides containing the CpG motif. CpG DNA has
applications in treating allergies such as asthma, immunostimulation
against cancer, immunostimulation against pathogens, and as adjuvants
in vaccines
-----
http://en.wikipedia.org/wiki/CpG_site
=================
HOW many hits for keywords: unmethylated CpG in the P NG
Geez, cheese, only six hits? Should be MOrE.
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?hl=en &group=alt.support.skin-diseases.psoriasis&q=unmethylated+CpG&qt_g=Search+this+g roup
Well, we pick up more dropping cpg: [14 hits --]
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?hl=en &group=alt.support.skin-diseases.psoriasis&q=unmethylated+&qt_g=Search+this+grou p
Is old reptillian looking DNA in side of us and does innate immunity
want to take those lizards right out of our lives? LOL
================================
This is OT (on Topic)
http://www.eurekalert.org/pub_releases/2009-06/elar-op061109.php
1/4 of patients on highest investigational doses of CP-690,550 achieve
ACR70 at week 12
Oral JAK-3 inhibitor candidate demonstrates dose-dependent efficacy in
active RA
Copenhagen, Denmark, Thursday 11 June 2009: A quarter of active
rheumatoid arthritis (RA) patients receiving either 10mg (24.6%) or
15mg (28.1%) twice daily of the investigational oral JAK-3 (janus-
associated kinase) inhibitor CP-690,550 (CP) achieved ACR70* after 12
weeks, according to the results of a new study presented today at
EULAR 2009, the Annual Congress of the European League Against
Rheumatism in Copenhagen, Denmark. The primary outcome for the study
was ACR20*, with 75.4% of patients achieving this measure at 12 weeks
for both 10mg and 15mg doses.
The study also showed that, comparatively, the ACR70* responses for
adalimumab (ADA, a monoclonal antibody and anti-TNF) and placebo, were
3.8% and 5.1% respectively at the same follow up point.
At the 12 week interim analysis, three doses (5mg, 10mg and 15mg twice
daily) of CP demonstrated statistical superiority to placebo in nearly
all clinical outcomes measured, including: ACR20, HAQ-DI** and
DAS28***, in patients who had had a previously inadequate response to
a DMARD (disease-modifying anti-rheumatic drug). Of patients receiving
15mg twice daily CP, 75.4% achieved ACR20 and 40.4% reached DAS28
remission; compared with 47.2% of ADA and 28.8% of placebo patients
for ACR20; and 4.4% of ADA and 6.7% of placebo patients for DAS28
remission respectively.
Dr Roy Fleischmann, Clinical Professor of Medicine, University of
Texas, Dallas, USA who led the study, said: "The development of oral
small-molecule JAK inhibitors, such as CP which targets the JAK-1/3
enzyme pathway, represents a new approach in the treatment of RA.
These drugs offer the potential for more precise targeting than
existing oral DMARD treatments, in addition to a more convenient oral
administration than biologic treatments. The results of this study
would suggest that the compound appears worthy for future phase III
investigation."
In the 6-month double-blind phase IIb dose-ranging study, 384 patients
were randomised to various trial doses of oral CP: 1mg, 3mg, 5mg, 10mg
and 15mg twice daily; or to ADA 40mg subcutaneous injection every
other week for 12 weeks followed by CP 5mg twice daily or placebo.
The most frequently-reported CP treatment-emergent all-cause AEs were
urinary tract infections (4.4%), diarrhoea (4.0%), bronchitis (3.7%),
and headache (3.7%). Most frequently-reported ADA treatment-emergent
all-cause AEs were bronchitis and pruritus (5.7% each), and blood
creatinine increase, dizziness, headache, influenza, nausea, rash, and
swelling (3.8% each).
The inclusion criteria for the study were as follows: patients with
active RA (6 tender joints and 6 swollen joints (66/68 joint count)),
and CRP (c-reactive protein) sedimentation rate) randomised to receive a study drug were female, with mean baseline
value ranges as follows: age 52.4 - 55.1 years; disease duration 7.7 -
11.0 years; HAQ DI 1.4 - 1.6; DAS28-3 (CRP) 5.4 - 5.6; and 70 - 83% RF
positive. The data presented at EULAR are taken from a week 12 interim
analysis of the 6-month study and include efficacy and safety
assessments taken at weeks: 2, 4, 6, 8, 10, and 12. The HAQ-DI
response was classified as a 0.22 unit improvement from baseline, and
DAS28 remission was set at DAS28-3 (CRP) achieving < 2.6.
Oral JAK inhibitors are also currently being investigated for a
variety of other therapeutic uses, including: other autoimmune
diseases (such as multiple sclerosis and psoriasis), prevention of
organ rejection following transplant and certain cancers.
------------------
This lawyer in hawaii has a nice story with good links (i provided) on
halofuginone today.
http://honolulu.injuryboard.com/fda-and-prescription-drugs/us-researchers-now-s uggest-that-selective-damping-down-of-the-th17-response-using-compounds-such-as- halofuginone-may-provide-an-answer-to-this-challenge.aspx?googleid=264488
They are beautiful flowering plants and now medical research
See:
http://www.childrenshospital.org/newsroom/Site1339/mainpageS1339P1sublevel539.h tml
has discovered a natural product in the Hydrangea, halofuginone, that
may help patients with autoimmune diseases like multiple sclerosis,
psoriasis, diabetes and many cancers.
To treat autoimmune diseases like MS you must stop tissue damage
without what is known as general immunosuppression. US researchers
think that an effective way to accomplish those competing goals is to
selectively reduce what is called the TH17 response
SEE:
http://en.wikipedia.org/wiki/Th17
using halofuginone from the Hydrangea.
The June 5th edition of the journal Science
SEE: http://www.sciencemag.org/cgi/content/abstract/324/5932/1334
reports that halofuginone specifically inhibits the development of
TH17 cells which are believed to play a key role in tissue injury in
autoimmune diseases such as inflammatory bowel disease, multiple
sclerosis, type 1 diabetes, eczema and psoriasis. As reported in Drug
Discovery this natural prod
When halofuginone was added to cultures of naïve mouse CD4+ T-cells
containing cytokines that would normally induce differentiation into
TH17 cells, the number of TH17 cells – but not TH1, TH2 or T
regulatory cells – was substantially reduced. In cultured human CD4+ T-
cells, halofuginone also selectively suppressed levels of IL-17, the
main cytokine produced by TH17 cells. In mice with experimental
autoimmune encephalitis (EAE), an artificially-induced immune disease
resembling multiple sclerosis and marked by infiltration of TH17 cells
into the central nervous system, treatment with low doses of
halofuginone significantly reduced both the development of EAE and its
severity.
To understand how halofuginone works, the researchers looked at
alterations in gene expression in response to drug treatment and found
that a cytoprotective signalling pathway, the amino acid starvation
response (AAR), was activated. Inhibition of TH17 differentiation by
halofuginone could be overcome by the addition of excess amino acids
and was mimicked by AAR activation in response to selective amino acid
depletion.
As reported in Forbes, Herb May Offer Hope for Autoimmune Diseases
SEE: http://www.forbes.com/fdc/welcome_mjx.shtml
"This is really the first description of a small molecule that
interferes with autoimmune pathology but is not a general immune
suppressant," said the study's lead study author, Mark Sundrud, from
the cellular and molecular medicine program and the Immune Disease
Institute at Children's Hospital Boston.
Autoimmune diseases occur when the immune system mistakenly attacks
and destroys healthy tissues and organs.
The disorders, which include multiple sclerosis, lupus and rheumatoid
arthritis, are difficult to treat because drugs that can suppress
inflammatory attacks by the immune system on body tissues often have
the side effect of suppressing the functioning of the immune as well.
Halofuginone is a synthetic analogue of febrifugine, the active
principal of the Chinese herb, chang shan (Dichroa febrifuga), which
has been used to treat fever and malaria for more than 2000 years.
Febrifugine itself causes severe emesis and gastrointestinal
irritation and, in the 1960s, a number of analogues – including
halofuginone – were synthesized by U.S. Army scientists looking for
novel antimalarials. Halofuginone also inhibits synthesis of
collagenase and collagen type 1 and underwent clinical trials for the
treatment of scleroderma, a chronic, autoimmune condition of the
connective tissue. In animal husbandry, halofuginone (as Stenerol®) is
used prophylactically to control coccidial infection in poultry
flocks.
What is Halofuginone?
http://www.fsis.usda.gov/ophs/clg/Halofuginone.pdf
================
Major OT...(ON topic)
With out a HOT sun we can generate enough vitamin D3.
SUN ALERTs.......................
Sunspots have gone quiet again. :(
Will we get back to a normal cycle soon?
If 2009 beats 1913 LOOK OUT
2007 to 2008 are pointing at a disaPPointing 2009 for SPOT.
That or an ice age could form?
http://www.prisonplanet.com/sunspot-minimum-may-be-at-hand.html
Sunspot Minimum May Be at Hand
By Joseph D’Aleo ICECAP
Thursday 4th June, 2009
The sun has become more active in recent days with cycle 24 spots in
middle latitudes. See sunspot group number 11019 for group of red
spots. This is slightly diminished since yesterday. The dark green
areas are coronal holes out of which the solar wind escapes at higher
velocity.
<sniP
Do you believe that CO2 is causing global warming?
READ this article: noah's ark revisited by andrew glikson
and see if your not in favor of immediate immplementation
of nuclear power ALL over the world?
http://www.thepeoplesvoice.org/TPV3/Voices.php/2009/06/08/noah-s-ark-revisited
==================
randall... gotta GO...blow this poPsickle stand...
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